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Specifically, lactylation is deposited on the activity enhancers in the NCC gene regulatory network, promoting chromatin accessibility and influencing NCC behavior like migration

Martinez-Outschoorn UE, Lin Z, Trimmer C, Flomenberg N, Wang C, Pavlides S et al

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For instance, lactylation of K508 on NSUN2, a typical methyltransferase responsible for RNA m 5 C modification, enhances its activity, facilitating GCLC m 5 C methylation and stabilizing GCLC mRNA, which enhances GSH production and reduces oxidative stress, thereby promoting gastric cancer cell survival

Therapeutic efficacy of sulforaphane in autism spectrum disorders and its association with gut microbiota: animal model and human longitudinal studies