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American Journal of PhysiologyLung Cellular and Molecular Physiology, 287(4), L774L783

L-buthionine-sulfoximine (BSO) is an inhibitor of the rate-limiting enzyme (GCLC) for GSH de novo synthesis

Its progressive dysfunction with agedecline in NAD+, accumulation of ROS, reduction in mitochondrial biogenesisis a central mechanism of aging and degenerative diseases

This example highlights a direct link between glutamine addiction and immune function in the tumor microenvironment

C., Nagy, P., Bianco, C

The 0.9% benzyl alcohol preservative supports repeated-access withdrawal from a single sealed vial when handled with proper aseptic technique