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Personalized medicine in diabetes mellitus: current opportunities and future prospects

In: ClancyKBHHindeKRutherfordJNeditors

1g), a marker indirectly associated with BBB dysfunction

10.1046/j.1471-4159.2002.01061.x J

Furthermore, although AD brain tissue frequently exhibits mitochondrial failure, new research has shown that peripheral mononuclear blood cells' mitochondrial activities have changed ( 3.2 Impaired electron transport chain function Alzheimer's disease is marked by decreased activity in several enzymatic complexes critical for ATP production, including the pyruvate dehydrogenase complex, -ketoglutarate dehydrogenase complex, complex I (NADH ubiquinone oxidoreductase), complex IV (cytochrome oxidase), and complex V (ATPase) (43, 44)