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Wiederhold et al., 2018)

The naturally occurring endocannabinoid anandamide also caused similar 24 h loss of cell viability in developing mouse cortical neurons at concentrations ranging from 1 to 100 mcg/mL, indicating the mechanism of cell death could be mediated through the cannabinoid receptors

Biochemical and Biophysical Research Communications, 530(1), 222-229

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Indeed, the United States Food and Drug Administration and the (United States) National Institutes of Health have recognized the need for updated approaches to the licensing of RBC products that incentivize the goal of improved clinical benefits in anemic patients receiving transfusion ( Red Blood Cell Storage Duration and Trauma Retrospective studies had indicated an increased risk of poorer outcomes following transfusion with longer-stored RBCs in trauma, ICU, and cardiac surgery patients