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It was noteworthy that oral L-theanine could also weaken the adverse reactions of S-1 adjuvant chemotherapy (75)

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Moreover, reactive toxic aldehydes among lipid peroxidation products such as 4-hydroxy-2-nonenal (4-HNE) or malondialdehyde (MDA) are confirmed as markers of oxidative stress-induced lipid peroxidation [17, 18]

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Another study suggest that the risk of nephrotoxicity increased with age, particularly in patients treated with cisplatin compared to carboplatin, due to the natural decline in nephron number and size with age, which makes older individuals more susceptibility to nephrotoxicity [65]

bronchial epithelial cell cytokine response models