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A compound that produces identical protective effects whether administered systemically or topically to the target tissue suggests both a circulating effector mechanism and a local tissue-level mechanism, consistent with the dual NO-VEGF angiogenic pathway described above

The response to GHRP2 in adults also suggests that rapid recrudescence of GHRH neuronal elements may be evoked by the ghrelin analog

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9 Kaidbey KH, Agin PP, Sayre RM, Kligman AM

Discordance Between Endocrine and Paracrine/Autocrine IGF-I An important example of metabolic and mitogenic consequences of an unbalanced endocrine versus autocrine/paracrine insulin-GH-IGF-axis comes from observations in children and adolescents with type 1 diabetes (Figure 5)

But Professor Samaras said the biggest potential risk was stimulating or promoting cancer