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Coma and respiratory failure in a child with severe vitamin B(1 2) deficiency

Sodium phosphate buffer (0.2 M), pH 7, was used as a mobile phase and dilution buffer for the mAb formulations

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doi: 10.22374/jomh.v15i3.156 38 CaiDYYangYPWuJXuSQGuoKMWangHLet al

Nicotinamide N-methyltransferase (NNMT) is a key enzyme located in the cytosolic milieu that catalyzes the transfer of methyl group from the co-factor S-(5-Adenosyl)-L-methionine (SAM) to substrates such as nicotinamide (NCA), pyridine, and related analogs, such as quinoline, isoquinoline, and the1,2,3,4 tetrahydroisoquinoline.aliphatic amine NNMT directly regulates the detoxification of endogenous and exogenous drugs/xenobiotics by the formation of methylated metabolic products, such as 1-methyl nicotinamide (1-MNA), methylated pyridiniums, and methylated related analogs