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Knockdown of CBS decreases bioenergetics, actions such as oxygen consumption and ATP production in colon and ovarian cancer cells ( 2 S might enhance glucose uptake by stimulating GLUT activity, thereby accelerating glycolysis

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These direct GHR-mediated metabolic effects are studied separately from the IGF-1-mediated anabolic axis using selective pathway inhibitors and GHR knockout models

Quercetin and other flavonoids are known to behave as mild prooxidants resulting in the upregulation of protective genes, such antioxidant enzymes, glutathione, and cytoprotective enzyme Heme Oxygenase HO-1 mediated by activation of the Nuclear factor erythroid 2-related factor 2 (NRF2), a transcription factor upregulating antioxidant response, expression of antioxidant enzymes, and cytoprotective proteins (Ma and He 2012)