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The evidence for injectable GHK-Cu producing systemic skin benefits is thin compared to topical use

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\n\n\n\n BPC-157 Organ Protection Research: Liver, Kidney, and Beyond \n\n\n\n Beyond the organ systems already discussed, preclinical research has explored BPC-157s potential protective effects across a broad range of additional tissue types including the liver, kidneys, cornea, and periodontal tissue a scope that underscores the compounds apparent systemic rather than tissue-specific mode of action

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J Clin Oncol (2013) 31(26):321925

Intracellular stores of Ca 2+ in the endoplasmic reticulum and mitochondria may also contribute to spine restricted signaling, although some studies have failed to find evidence for this