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Contemp Clin Dent 4:176180 Percival SS (1998) Copper and immunity

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[58] Another study using intravenous infusion of n-acetylcysteine (2 hour infusion of 150 mg/kg, followed by 15 mg/kg/hour for 5 days) resulted in significantly reduced digital ulcers and lower mean recovery time on cold challenge test in 22 patients of systemic sclerosis

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In vitro , low mM concentrations (e.g., 8.5 mM) reduce TEER and increase permeability across Caco-2 monolayers without compromising epithelial integrity, suggestive of a paracellular mechanism (Lindmark et al., 1995)