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Some studies also state the roles played by mitochondria and the TrpKYN system, their interactions and their involvement in preclinical and clinical research on serious neurological and psychiatric diseases [22]

doi: 10.1007/s00011-024-01984-4 268 LiuYLiuTZhouYLiWWangMSongNet al

Affective disorders and depression are associated with high levels of oxidative stress markers [such as 8-hydroxydeoxyguanosine (8-OHdG)], proinflammatory cytokines (such as interleukins (IL) IL-1 and IL-6 and tumor necrosis factor alpha (TNF)), as well as with decreased levels of antioxidants (such as coenzyme Q10, glutathione peroxidase, and zinc) (Ng et al., 2008