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Lesiak B, Trykowski G, Tth J, Biniak S, Kvr L, Rangam N, et al

Trends Cardiovasc Med (2017) 27:13640

Full-length SARS-CoV S (GenBank: AY278741.1) and SARS-CoV-2 S, E, M, and N (GenBank: NC_045512.2) genes were synthesized by Genscript Inc (USA) as human codon-optimized cDNAs, and inserted into pcDNA3.1 expression vectors

These approaches primarily function through mechanisms including the replacement of defective mtDNA/nDNA, antioxidation, metabolic regulation, and mitochondrial protection