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According to Neuwelt, brain tumours, epilepsy, Alzheimers disease and Parkinsons disease are all associated with perturbations in the normal BBB that contribute to their pathology. 5 Information on the status of the barrier in a particular patient may be necessary to devise and refine appropriate therapies

The process can be initiated by elevated glucose or insulin, and liver X receptor A, thereby promoting hepatic lipid accumulation and regulating to lipid-producing genes such as Acetyl-CoA Carboxylase (ACC), Stearoyl-CoA Desaturase-1, and Fatty Acid Synthase (FASN) (Geidl-Flueck and Gerber 2023

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Previously in an open-label pilot investigation, UDCA demonstrated some beneficial effects on hepatic enzymes and degree of steatosis (at biopsy) in NASH patients [191]