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Insulin sensitivity increased substantially across all dose groups

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71,72 To account for differences between drugs, such as the 1 AR antagonist activity of carvedilol, we ran sensitivity analyses with each drug removed and found similar risks (data not shown), suggesting that our results cannot be attributed to any single compound

Neutrophil-mediated inflammatory responses are considered to play key roles in COPD pathogenesis ( Currently, COPD treatment mainly includes bronchodilators, inhaled corticosteroids, and phosphodiesterase-4 inhibitors, but these therapeutic approaches have relatively limited effects on neutrophil-mediated inflammation (Wedzicha et al., 2016)