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These side effects can often be managed by taking the medication with food, taking a drug holiday, switching to an extended-release formulation, or starting with a low dosage and gradually increasing over time (Wexler 2021b)

To find out why, researchers tested the liver cells to see what had changed in the depressed mice

Throughout the experimental period, general clinical conditions were continuously monitored, including the presence of piloerection, cyanosis, dyspnea, changes in spontaneous activity or gait, tremors, convulsions, abnormal bodily secretions, and excretory abnormalities

Research comparing GHK-Cu to retinoic acid found that the peptide stimulated collagen production with significantly less irritation