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Knovich MA, Storey JA, Coffman LG, Torti SV, Torti FM

GCLM interacts with GCLC, making the GCL holoenzyme kinetically more efficient in glutathione synthesis since GCLC has a very high Km for l-glutamate compared to when it is complexed with GCLM 32,33

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The age-related changes in LMW iron are consistent with increased labile iron, which is withdrawn as the substrate for ferroptosis by SIH treatment

Additionally, these two branches of IGF-1-R canonical pathways show cross-talk under specific circumstances (59)