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GLP-1 agonists are typically longer peptides (around 30-40 amino acids) often modified to resist enzymatic degradation, making them structurally and functionally distinct

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Under hypoxic conditions, the tumor promotes angiogenesis towards the surrounding blood vessels by hypersecreting proangiogenic factors, such as vascular endothelial growth factor (VEGF), insulinlike growth factors (IGF1), fibroblast growth factor2, plateletderived growth factor, the angiopoietins, hepatocyte growth factor, tumor necrosis factor, and interleukin6 (Potente et al , 2011