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Specifically, loss of function variants identified in Nicastrin (NCSTN), Presenilin Enhancer 2 (PSENEN2), Presenilin 1 (PSEN1), Aph-1A and Aph-1B Gamma-Secretase Subunits (APH1A and APH1B) genes, lead to haplo-insufficiency that ultimately results in defective Notch signaling [46,47,48,49,50]

As such, we proposed to codify at 427.201(b) that we will compare the published payment amount in the quarterly pricing files published by CMS to determine whether a coinsurance adjustment applies

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Specifically, higher ROS concentrations might selectively target cancer cells through ROS-mediated apoptosis, while lower ROS levels generated during autooxidation may stimulate antioxidant defenses via Nrf2 activation