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This could be important for its healing properties, as wider blood vessels can deliver more blood, oxygen, and nutrients to injured tissues

It has been reported that taVNS may inhibit peripheral inflammatory responses by modulating the 7nAChR/JAK2/STAT3 signaling pathway in the spleen, reducing the release of chemokine C-X-C Motif Chemokine Ligand 1 (CXCL1) and exerting anti-inflammatory effects, thereby improving LPS-induced depressive-like behaviors in rats (105)

Wet-wrap treatment using cream or ointment and a double layer of cotton bandages, with a moist first layer and a dry second layer, is an efficacious short-term intervention treatment in children with severe and/or refractory AD

Cell 165, 153164

doi:10.1186/s12964-023-01364-1 Hao Z, Guo S, Tu W, et al

The most important factor is consistency of timing and route day to day, since the mechanism works cumulatively rather than as an acute event to time around a meal