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Notably, the DHE-positive staining in the aortic root sections of the P-Mn/TI@mHSA group was remarkably low, showing reductions of 3.35- to 1.50-fold compared to the other groups (Fig

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In an autocrine mechanism, SASP factors reinforce the cellular senescence of the senescent cells themselves, while in a paracrine mechanism, they are responsible for inducing senescence in surrounding cells [35]