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We've learned that we start with the dose based upon these, like you said, animal studies, which is conservative, make sure it's safe

Firstly, it protects drugs against environmental influences, enhancing their stability and bioavailability

J Ren Nutr 16(2):141149 Rabkin R, Sun DF, Chen Y, Tan J, Schaefer F (2005) Growth hormone resistance in uremia, a role for impaired JAK/STAT signaling

The dosage and duration of therapy should be individualized by the physician according to the patients response and underlying cause of deficiency

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doi: 10.1089/ars.2017.7423 3 BansalNMimsJKuremskyJGOlexALZhaoWYinLet al