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Pegloticase may be especially useful in patients with very large collections of uric acid (tophi), especially if these are draining to the skin

You have no way to determine how much potency has been lost, which means you cannot calculate an appropriate dose adjustment

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Finally, the MDA contents were measured by thiobarbituric acid (TBA) reaction with a Malondialdehyde (MDA) Assay Kit (Solarbio Science & Technology Co., Ltd., China, BC0025) based on the manufacturers instructions