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Citrulline is generally well-tolerated with fewer gastrointestinal side effects than arginine

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Thus, supplementary oxygen may be administered under high pressure (hyperbric) by either housing the dog in an oxygen cage (right) or a nasal tube, called a cannula

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Response to Retention Hypothesis for the Initiation of Atherosclerosis The response to retention hypothesis holds that retention of atherogenic lipoproteins in the artery wall is a critical initiating event that sparks an inflammatory response and promotes the development of atherosclerosis (Figure 1)