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In contrast to the placebo-treated subjects who experienced minimal changes in body weight over the 16-week treatment period, the pramlintide-treated subjects attained significant weight loss from baseline as early as week 2, which was progressive up to week 16, with no evidence of a plateau

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NNMT (nicotinamide N-methyltransferase) is an enzyme found in fat cells and other tissues that can become overactive in certain metabolic conditions

Generally, 24 to 36 months , depending on packaging and storage conditions

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