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For the U87MG model, male CB-17 severe combined immunodeficient (SCID) mice (8 weeks old, n = 5 or 6 per group) were purchased from Japan SLC (Shizuoka, Japan)

[Interesting fact treatment of OTC deficiency made headlines in 1999 when Jamie Gelsinger, an 18-year-old with mild OTC deficiency died during a gene therapy trial

in migraineurs typical migraine syndromes ensued

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PMID: 33996490

We searched for glycolytic enzymes whose expression is essential for survival of cancer cells with high xCT expression and identified the glucose transporter GLUT1