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These include: High blood pressure Smoking Hyperlipidemia (high levels of fat in the blood) Diabetes A higher-than-healthy body mass index (BMI) Dyslipidemia (abnormal amount of lipids in the blood) Irregular heart rhythms (such as atrial fibrillation) Conditions that make your blood more likely to clot Heart disease, including rheumatic heart disease and other heart valve diseases Male gender Up to 40% of people with CRAO are found to have significant narrowing of the carotid artery on the same side

63 At the cellular level, aging is characterized by a progressive decline in homeostatic mechanisms, including impaired proteostasis, mitochondrial dysfunction, dysregulated nutrient sensing, and chronic, low-grade inflammation

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ROS can activate MMPs (including MMP-2) and simultaneously decrease concentrations of TIMPs (including TIMP-2) and this can contribute to BBB permeability (68)

FRET modulated signaling: a versatile strategy to construct photoelectrochemical microsensors for in vivo analysis

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