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A typical acute injury protocol begins with 0.25 mg twice daily for the first week, reduces to 0.5 mg once daily for weeks two through four, then continues at 0.25 mg daily for weeks five and six if needed

Using Kaede photoconvertible mice, experiments demonstrated that CD8+ effector T cells that enter and stay in the tumor develop an exhausted phenotype within 72 hours, whereas non-effector TCF1+ stem-like CD8+ T cells are continuously trafficked between the tumor and the TDLNs (97) ( Figure 3 )