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Cells labelled with full-length CBS (mKO2-CBS FL ) exhibited an aggregated fluorescence pattern consistent with cryo-EM-identified filament structures

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After discontinuation, close monitoring is essential: weight should be checked every 4-8 weeks initially, and for diabetes patients, self-monitoring of blood glucose or continuous glucose monitoring should continue as indicated, with A1C assessment within approximately 3 months of stopping to detect metabolic deterioration early and implement alternative management strategies