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Acknowledgments This work was supported by a faculty start-up fund from Pennsylvania State University, and the USDA National Institute of Food and Federal Appropriations under Hatch Project #PEN04938 and Accession #7006507 (F.Z.)

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Additionally, people experiencing fatigue, memory issues, or neuropathy should consider Vitamin B12 supplementation, especially if they don't consume B12-enriched foods

The contribution of reactive astrocytes to neurodegenerative diseases and cognitive impairments is now well established

It is well known that TNF- is closely related to tumorigenesis 83,84