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All patients received 12 doses of IV busulfan

Published rodent pharmacokinetic data report a plasma half-life consistent with once- or twice-daily oral administration for sustained NNMT inhibition

c , Heart weights of mice in Extended Data Figs

doi: 10.3389/fncel.2015.00423 12 AytonS.LeiP.DuceJ

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[DOI] [PMC free article] [PubMed] [Google Scholar] 83.Vaur P., Brugg B., Mericskay M., Li Z., Schmidt M.S., Vivien D., Orset C., Jacotot E., Brenner C., Duplus E