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A study revealed that PARP inhibition induces ferroptosis via p53-mediated SLC7A11 downregulation, depleting glutathione and increasing ROS-driven lipid peroxidation in BRCA-mutant ovarian cancer

doi: 10.1007/s12035-019-01780-w 35 DowdingJ

22 July 2014, 53 (28): 473953

Br J Nutr (2011) 105:75564

NAPQI-modified Cys15, 48, and 78 were uniquely found in trypsin digests, whereas Cys112 and 170 were only found after pepsin digestion

High expressions of SIRT3 in cerebral cortical and hippocampal cells could benefit for treating anxiety and cognitive disorders, which was found as considerable overlap mechanisms by which IF and exercise enhance brain function of Alzheimers Disease patients (39, 40)