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Intervention studies have shown that supplementation with riboflavin (the MTHFR cofactor) effectively lowers blood pressure, specifically in individuals with the variant MTHFR 677TT genotype

Biomarkers for oralization during long-term proton pump inhibitor therapy predict survival in cirrhosis

This protective action can also lead to better post-exercise recovery for active individuals

2002 Apr;118(4):565-72

Age-dependent effects of UCP2 deficiency on experimental acute pancreatitis in mice

Moore MP, Cunningham RP, Meers GM, Johnson SA, Wheeler AA, Ganga RR, Spencer NM, Pitt JB, Diaz-Arias A, Swi AIA, Hammoud GM, Ibdah JA, Parks EJ, Rector RS