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Disruptions in energy homeostasis and metabolism emerge in ALS and are considered central to disease pathogenesis 11,12

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The nucleophile penicillamine is able to ameliorate the impact of acute treatment with H 2 O 2 on oocytes Taken together, our data raise the intriguing prospect that the structural perturbation of tubulin that is induced by 4-HNE adduction may, at least in part, contribute to increased aneuploidy rates observed in oocytes exposed to elevated levels of OS

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