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Sanchez-Jimenez P, Elizalde-Horcada M, Sanz-Garcia A, Granero-Cremades I, De Toledo M, Pulido P, et al

First, in the extrinsic pathway xenobiotics interact with so-called death receptors ( e.g ., Fas, also called Apo-1 or CD95) or tumor-necrosis factor receptor, TNF-R) to cause activation of the death-inducing signaling complex (DISC)