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Because there's no safety data, the FDA says it may be harmful to people using it

Risk of Life-Threatening Respiratory Depression and Concomitant Use of Benzodiazepines or Other CNS Depressants with Buprenorphine: Buprenorphine has been associated with life-threatening respiratory depression, overdose, and death, particularly when misused by self-injection or with concomitant use of benzodiazepines or other CNS depressants (e.g., alcohol, nonbenzodiazepine sedative/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids [gabapentin or pregabalin], and other opioids)

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Describe what happens when you try

Step 4: inject air into the vial Insert the needle through the rubber stopper

Tyrosine hydroxylase phosphorylation in vivo