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2018;10: aafe7444

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4,52,53 A less common but important genetic factor affecting homocysteine metabolism pertains to the CBS gene, which encodes the enzyme cystathionine beta-synthase (CBS)

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In addition, the observed differential 1-MNA steady-state levels following NNMT inhibition may reflect differential transcriptional regulation of cellular metabolic pathways across the various stages of 3T3-L1 differentiation;[38] for example, aldehyde oxidase (AOX)-mediated degradation of 1-MNA may be more pronounced in pre-adipocytes compared to adipocytes, thereby synergistically reducing 1-MNA levels to a greater extent in pre-adipocytes compared to adipocytes

doi: 10.3389/fnana.2024.1419108 Received 17 April 2024 Accepted 04 September 2024 Published 29 October 2024 Volume 18 - 2024 Edited by Huijiao Liu, China Agricultural University, China Reviewed by Claudio Da Cunha, Federal University of Paran, Brazil Jordi Bov, Vall dHebron Research Institute (VHIR), Spain Updates Copyright 2024 Pedro, Medeiros, Leandro and Falquetto