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142 Moreover, it was revealed that neither shikimate- nor methionine-labeled plumbagin strongly indicating that its synthesis (and by extension, the synthesis of droserone, 5- O -methyldroserone and 7-methyljuglone) does not proceed through a juglone intermediate derived from the OSB pathway (Figure 2)

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In addition to CYP-mediated phase I metabolism, many ACDs undergo phase II conjugation reactions, in which drug molecules combine with endogenous substances such as glucuronic acid or sulfate to form highly polar inactive metabolites for excretion