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Description

137 Although recent studies support a role for NLRP3 inflammasomes in APAP-induced liver injury, the discrepancies and complexity of available data underscore the need for further research

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HPV promotes carcinogenesis through OS by various mechanisms, such as altering mitochondrial cristae, raising ROS levels and DNA damage by lowering the SOD 2 and GPx 1/2 antioxidant, activating the EGFR/MEK/ERK cell signaling pathway, and upregulating the OS sensor Pirin, and also causing LDHA translocation due to elevated ROS caused by HPV oncoprotein and subsequent methylation of histone H3K79