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While your body can use those amino acids to try and rebuild glutathione, it is an inefficient process that doesn't always lead to higher cellular levels

123 Patient-derived hepatocyte and cholangiocyte models have also been studied and have shown the ability to use induced pluripotent stem cell-derived cells to study variant-specific targeted drug responses

Indeed, an independent mechanism of the oxidant stress might be involved in the formation of the fibrous atherosclerotic lesion observed in hyperhomocysteinemia

Tsimberidou A, Thomas DA, OBrien S, Andreeff M , Kurzrock R, Keating M, Albitar M, Kantarjian HM, Giles FJ

Mol Pharmacol 46:909914 Kim SK, Woodcroft KJ, Khodadadeh SS, Novak RF (2004) Insulin signaling regulates gamma-glutamylcysteine ligase catalytic subunit expression in primary cultured rat hepatocytes

Respiration 97, 119124