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Moreover, miR-377 expression is markedly upregulated in passaged senescent human skin fibroblasts (HSFs) and can expedite HSF senescence by targeting DNA methyltransferases

Studies in model organisms, particularly yeast, have significantly advanced our understanding of this pathway [38], though some aspects of human ALA biosynthesis remain under investigation

IL6 Derived from Macrophages under Intermittent Hypoxia Exacerbates NAFLD by Promoting Ferroptosis via MARCH3-Led Ubiquitylation of GPX4

Twenty-four hours (Nrf2), respectively 48 h (CYPOR) after seeding, treatment of the cells with NFT was initiated

Prevotellaceae holds a dual identity: on one hand, many members within the family (e.g., Prevotella copri) are often overrepresented in various liver disease, playing a "bad role" by disrupting the intestinal barrier, producing harmful metabolites, and exacerbating the condition [184]

Altman BJ, Stine ZE, Dang CV