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doi: 10.1038/s41590-022-01415-8

Des surdoses svres peuvent mme entraner une toxicit

Sirtuin proteins, although known to primarily be histone deacetylases, can also localize in non-neuronal subcellular regions, thereby participating in other metabolic processes

31 Because serine is required (1) for the conversion of folic acid to its active form, (2) as a shuttle for methyl groups between the cytosol and the mitochondria, and (3) as a cofactor in the transsulfuration pathway of methionine/homocysteine metabolism, supplementation with betaine should be included with folic acid, cobalamin, and P5P to optimize the interrelated pathways of homocysteine metabolism

10.1016/j.molcatb.2016.11.019 6 BarglowK