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GLP-1 Agonist Semaglutide Brand names: Ozempic (diabetes) Wegovy (weight loss) 1517% Average body weight reduction (STEP trials) Activates GLP-1 receptors in gut and brain Suppresses appetite, slows gastric emptying Regulates blood sugar and insulin response Weekly subcutaneous injection or daily oral (Rybelsus) Cardiovascular outcome data: SELECT trial (2023) Dual GLP-1 + GIP Agonist Tirzepatide Brand names: Mounjaro (diabetes) Zepbound (weight loss) 2022% Average body weight reduction (SURMOUNT trials) Activates both GLP-1 AND GIP receptors Stronger effect on insulin sensitivity than semaglutide alone Greater fat loss, especially visceral fat Weekly subcutaneous injection only Head-to-head vs semaglutide: SURPASS-6 favors tirzepatide The core difference is the receptor target

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Most treatment discontinuations were due to gastrointestinal AE and occurred during the rapid escalation phase this may be mitigated with more gradual dose escalation at phase 3 trials

PMID: 35308055

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Dosage varies depending on symptoms and severity