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Mixing your own compounds can cancel out their benefits or cause unwanted side effects

Rufino AT, Ribeiro M, Sousa C, Judas F, Salgueiro L, Cavaleiro C, Mendes AF (2015) Evaluation of the anti-inflammatory, anti-catabolic and pro-anabolic effects of E-caryophyllene, myrcene and limonene in a cell model of osteoarthritis

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In fact, research on CBD has demonstrated that it affects how redox-sensitive transcription factors like nuclear factor erythroid 2related factor 2 (Nrf2) are controlled in microglia (87), keratinocytes (88) and endothelia (89), It is critical because Nrf2 is necessary for cytoprotective and antioxidant gene transcription to begin (90)

& Gangestad, S