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Le Blanc S, Villarroel P, Candia V, Gavilan N, Soto N, Perez-Bravo F, et al

60,61 In the CNS, they play a major role in dynamic signaling such as clearing waste, tuning brain blood flow, regulating vascular function, ion hemostasis and balancing neuroimmune responses

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These alterations occur in particular in the central DNA-binding domain (DBD) and are classified as mutations affecting DNA contact, as a result of changes of critical amino acids indispensable for p53 binding, such as R248Q (rs11540652), R273H (rs28934576), and R282W (rs28934574), or conformational mutations that lead to either a loss of protein structure or altered conformation, such as R175H (rs28934578), Y220C (rs121912666), G245S (rs28934575), and R249S (rs28934571) (Zhou et al

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