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In Group 4, there was a significant difference between the percentage of beta and glucagon cells with moderate GPX1 staining intensity ( p = 0.005)

Therefore, it is essential to thoroughly validate mouse findings in humanized models, like patient-derived iPSC 3D brain organoids, to ensure they are applicable to humans

the individual preparations are preferred when researchers need independent dose-response curves on each compound

ABCB4 mutations, involved in PFIC3, ICP, and LPAC syndrome, have mostly missense variants in heterozygosity in patients with late-onset diseases