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In Cohort 1, 25 WT and 25 RAMP1/3 KO male mice aged 1220 weeks old were injected intraperitoneally after a 12-hour fast with vehicle, sCT at doses of 3 or 150 nmol/kg, or Cagrilintide at a dose of3 nmol/kg

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Some trial participants showed total body weight reductions in the 20-25% range, though these figures come from smaller, shorter studies and should be interpreted with caution until phase 3 data is published