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Cancer Res 79 , 423436 (2019)

| 170 VatherR.JosephsonR.JaungR.RobertsonJ.BissettI

10.3389/fmed.2022.964101 53 SinhaS

Correspondingly, the downregulation of Col2a1 and upregulation of Mmp13 in the articular cartilage layer of aging mice also showed significant improvements after the JAKi treatment (Supplementary Fig

The hydrogen-carbon bonds on these methylene units have very low bond-dissociation energy, making the hydrogen atom to be abstracted easily in the radical reactions (Davies and Guo, 2014)