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Acyl-CoA thioesters possess an electrophilic carbonyl-carbon and are able to undergo non-enzyme catalyzed transacylation reactions with biological nucleophiles leading to covalent binding to protein and drug-protein adduct formation

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Many animal studies have reported that glutathione exerts an agonistic effect on NMDA receptors.8791 However, in the presence of uncontrolled and persistent chronic oxidative stress, glutathione level is decreased and leads to NMDA receptor dysfunction.9293 Deficits in glutathione level are associated with neurological deficits in various neuropsychiatric diseases.94 Glutathione regulates redox-sensitive sites such as the NMDA receptor

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