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they found that the c-MET inhibitor tivantinib reduces the synthesis of GSK3 by inhibiting MET activation, thereby stabilizing the expression of PD-L1 and blocking T cell-mediated cytotoxicity [139]

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Adverse events were mild and reversible

Melatonins production peaks at the dark phase of the day and is suppressed by light [174], with evidence of being effectively suppressed by short-wavelength blue light [175]