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AMG 133 demonstrated significant dose-dependent weight loss in a phase 1 randomized, double-blind, placebo-controlled clinical trial involving participants with obesity, along with an acceptable safety and tolerability profile [124]

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Its deficiency may lead to impaired wound healing, accelerated skin aging, and, in severe cases, scurvy (241, 243)

For example, asthmatic responses and autoimmune arthritis could be effectively cured by imatinib (Paniagua et al., 2006)

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